Mix the Panko breadcrumbs, regular breadcrumbs, Italian seasoning, salt, garlic powder, onion powder, and lemon pepper in a small bowl or Ziploc bag. Set aside.
Unpack, dry the chicken with a paper towel, and place it on a plate. Trim any excess fat or cut the chicken so each piece is the same size.
Using a pastry brush, brush the sour cream on the chicken breast, on both sides. If you don't have a brush, use the back of a spoon or knife.
Place the coated chicken into the breadcrumb mixture, either in your bowl or the Ziploc bag.
If using a Ziploc bag, seal the bag and shake it up to coat the chicken. If using a bowl, roll the chicken in the mixture to fully coat.
Place the chicken into the air fryer basket, depending on size, it may need to be done 2 per batch.
Coat the chicken with grapeseed oil spray. This is optional; however, it will make the chicken more crispy.
Cook at 380°F for 13-15 minutes. Flip the chicken halfway through the cooking time.
The internal temperature should be at least 165°F to be considered done.
Place on a cooling rack and serve or continue making the remaining batch.
If you want to keep it warm while cooking another batch, place in the oven at 200°F on a baking sheet to keep warm.